Folate vs Vitamin B6

Evidence-based comparison of Folate and Vitamin B6 — absorption, dosage, safety, and which is best for your needs.

Vitamin B6

Mitochondrial support: Enhances mitochondrial efficiency and biogenesis; Serotonin modulation: Influences serotonin synt

Full Guide

Detailed Comparison

FolateVitamin B6
CategoryVitaminVitamin
MechanismSerotonin modulation: Influences serotonin synthesis; Dopamine modulation: Influences dopamine synthesis or receptor actMitochondrial support: Enhances mitochondrial efficiency and biogenesis; Serotonin modulation: Influences serotonin synt
SafetyFolate that is naturally present in food and beverages is not harmful. However, you should not consume folate in supplements or fortified foods and bePeople almost never get too much vitamin B6 from food or beverages. However, taking high amounts of vitamin B6 from supplements for a year or longer c

Which Should You Choose?

Folate may be better if: Serotonin modulation: Influences serotonin synthesis; Dopamine modulation: Influences dopamine synthesis or receptor activity; Homocysteine reduction:

Vitamin B6 may be better if: Prospective studies on vitamin B6 supplements to treat morning sickness have had mixed results. In two randomized, placebo-controlled trials, 30–75 mg of oral pyridoxine per day significantly decrease