Vitamin B12 vs Folate
Evidence-based comparison of Vitamin B12 and Folate — absorption, dosage, safety, and which is best for your needs.
Vitamin B12
Mitochondrial support: Enhances mitochondrial efficiency and biogenesis; Serotonin modulation: Influences serotonin synt
Full GuideFolate
Serotonin modulation: Influences serotonin synthesis; Dopamine modulation: Influences dopamine synthesis or receptor act
Full GuideDetailed Comparison
| Vitamin B12 | Folate | |
|---|---|---|
| Category | Vitamin | Vitamin |
| Mechanism | Mitochondrial support: Enhances mitochondrial efficiency and biogenesis; Serotonin modulation: Influences serotonin synt | Serotonin modulation: Influences serotonin synthesis; Dopamine modulation: Influences dopamine synthesis or receptor act |
| Safety | Vitamin B12 has not been shown to cause any harm, even at high doses. | Folate that is naturally present in food and beverages is not harmful. However, you should not consume folate in supplements or fortified foods and be |
Which Should You Choose?
Vitamin B12 may be better if: Maruvada P, Stover PJ, Mason JB, Bailey RL, Davis CD, Field MS, et al. Knowledge gaps in understanding the metabolic and clinical effects of excess folates/folic acid: A summary, and perspectives, fro
Folate may be better if: Serotonin modulation: Influences serotonin synthesis; Dopamine modulation: Influences dopamine synthesis or receptor activity; Homocysteine reduction: