Vitamin C vs Vitamin B12

Evidence-based comparison of Vitamin C and Vitamin B12 — absorption, dosage, safety, and which is best for your needs.

Reviewed by: Supplement Hub Editorial Team · Category: Vitamin · Updated:

Vitamin C

Neuroprotection: Protects neurons from oxidative and excitotoxic damage; HPA axis modulation: Modulates hypothalamic–p

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Vitamin B12

Mitochondrial support: Enhances mitochondrial efficiency and biogenesis; Serotonin modulation: Influences serotonin synt

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Detailed Comparison

Vitamin CVitamin B12
CategoryVitaminVitamin
MechanismNeuroprotection: Protects neurons from oxidative and excitotoxic damage; HPA axis modulation: Modulates hypothalamic–pMitochondrial support: Enhances mitochondrial efficiency and biogenesis; Serotonin modulation: Influences serotonin synt
SafetyTaking too much vitamin C can cause diarrhea , nausea , and stomach cramps. In people with a condition called hemochromatosis , which causes the body Vitamin B12 has not been shown to cause any harm, even at high doses.

Which Should You Choose?

Vitamin C may be better if: Vitamin C is an essential antioxidant that supports immune function and collagen synthesis. Most people can get adequate vitamin C from fruits and vegetables.

Vitamin B12 may be better if: Maruvada P, Stover PJ, Mason JB, Bailey RL, Davis CD, Field MS, et al. Knowledge gaps in understanding the metabolic and clinical effects of excess folates/folic acid: A summary, and perspectives, fro