B1 Dosage Guide

Our assessment

Based on the available data, thiamin has not been shown to cause any harm NIH ODS ↗. This positions it as a supplement with a very favorable safety profile, meaning that the risk of adverse effects from standard use appears to be minimal based on current evidence.

How it works

Thiamin, also known as vitamin B1, is essential for converting food into energy and is critical for nerve function. While specific data on its mechanism of action is not provided here, its role in energy metabolism is well-established NIH ODS ↗.

Safety profile

Data not available for specific FDA adverse event reports or side effect counts. The provided safety information indicates that thiamin has not been shown to cause any harm NIH ODS ↗.

Our recommendation

Individuals taking certain medications should be aware of potential interactions. Specifically, Furosemide (Lasix), used for high blood pressure and fluid retention, and Fluorouracil (5-fluorouracil and Adrucil), a chemotherapy drug, can lower thiamin levels in the body FDA FAERS ↗. If you are taking these medications, discuss your thiamin status with your healthcare provider. As no harm has been shown, thiamin is generally considered safe, but always consult a doctor before starting a new supplement regimen NIH ODS ↗.

Dietary Reference Intakes (DRIs) are a set of reference values used to plan and assess nutrient intakes of healthy people. They include:

• RDA (Recommended Dietary Allowance) — The average daily intake sufficient to meet the nutrient requirements of nearly all (97-98%) healthy individuals.
• AI (Adequate Intake) — Established when evidence is insufficient to develop an RDA. Based on observed nutrient intake by healthy people.
• UL (Tolerable Upper Intake Level) — The maximum daily intake unlikely to cause adverse health effects. Exceeding the UL increases the risk of toxicity.

Values vary by age, gender, and life stage (pregnancy, lactation).

Source: National Academies of Sciences, Engineering, and Medicine