Kirkland Signature Premium Performance Multi
Brand: Kirkland Signature · Form: TABLET [E0155]
Our assessment
The evidence shows that Kirkland Signature Premium Performance Multi is a comprehensive multivitamin, but its value depends entirely on your individual needs. The key ingredient to focus on is calcium, which supports bone mineralization and neuromuscular relaxation [NIH ODS]. However, you should be cautious: some research suggests that high calcium intakes might increase the risk of heart disease and prostate cancer [NIH ODS]. The total number of FDA adverse event reports for this product line is 592059, which includes all reports for the brand, not just this specific formula [FDA data].
How it works
Think of calcium as a structural and signaling mineral. It supports bone density through bone mineralization and helps your muscles relax and nerves signal properly [NIH ODS]. This multivitamin provides a baseline of calcium, but the exact dose per serving is listed on the label. You should compare that amount to your total daily intake from food and other supplements to avoid exceeding safe levels.
Safety profile
Safety data for this product includes 592059 total adverse event reports [FDA data]. Specific risks from calcium include constipation, nausea, weight loss, extreme tiredness, frequent need to urinate, abnormal heart rhythms, and a high risk of death from heart disease — but these are associated with high levels in the blood and urine [NIH ODS]. Calcium can also reduce the absorption of several medications, including bisphosphonates, tetracycline antibiotics, fluoroquinolone antibiotics, levothyroxine, and phenytoin [NIH ODS]. You should take this multivitamin at least 2 hours apart from those medications.
Our recommendation
Our assessment: This multivitamin is a reasonable choice if you need a general supplement, but do not rely on it as your primary calcium source. Check your total daily calcium intake from all sources — including food — and aim for the RDA. If you take medications like thyroid hormone or certain antibiotics, separate your doses by at least 2 hours [NIH ODS]. Start with one tablet daily with food and monitor for any side effects like constipation or nausea [NIH ODS]. If you have a history of kidney stones or heart disease, consult your doctor before use [NIH ODS].
AI-assisted analysis. Data sourced from NIH DSLD.
Supplement Facts
| Brand | Kirkland Signature |
|---|---|
| Serving Size | |
| Contents | 300.0 Tablet(s) |
| Market Status | Off Market |
How to Read This Label
Supplement labels contain several key sections regulated by the FDA:
- Serving Size — The recommended amount per dose. Always check this — some products require multiple capsules per serving.
- Amount Per Serving — Shows the quantity of each nutrient in the product, typically in IU (International Units), mg (milligrams), or mcg (micrograms).
- % Daily Value (%DV) — Indicates how much a nutrient in a serving contributes to a daily diet. 5% DV or less is low; 20% DV or more is high.
- Other Ingredients — Lists inactive ingredients like fillers, binders, and capsule materials (e.g., gelatin, cellulose, magnesium stearate).
- Suggested Use — The manufacturer's recommended directions for taking the supplement, including timing and dosage.
Source: FDA Dietary Supplement Labeling Guide