Major Calcitrate Calcium Citrate + D3
Brand: Major · Form: SUPPLEMENT FORM, OTHER [E0172] On Market
Our assessment
Our assessment: Calcium with vitamin D3 is a foundational supplement for bone health, but the evidence shows you need to be precise with dosing. The data confirms calcium supports bone mineralization and neuromuscular relaxation [NIH ODS]. For most adults, the goal is to meet, not exceed, your daily needs.
How it works
Think of calcium as the building block for your skeleton — it deposits into bone tissue to maintain density and strength. Vitamin D3 helps your body absorb that calcium efficiently. Together, they also support muscle relaxation and nerve signaling, which is why you may feel better with consistent intake [NIH ODS].
Safety profile
The FDA has received 592,059 total adverse event reports across all supplements, though specific counts for this product are not broken out. The data shows that high calcium intakes can cause serious risks: constipation, nausea, weight loss, extreme tiredness, frequent urination, abnormal heart rhythms, and a high risk of death from heart disease. High blood and urine calcium levels can also lead to poor muscle tone, poor kidney function, and low phosphate levels [NIH ODS] [FDA data]. Additionally, calcium can reduce the absorption of bisphosphonates, tetracycline antibiotics, fluoroquinolone antibiotics, levothyroxine, and phenytoin [NIH ODS].
Our recommendation
Start by checking your total calcium intake from food and other supplements. Do not exceed the tolerable upper intake level unless directed by your doctor. Take calcium with meals, and separate it from thyroid medication or antibiotics by at least 2 hours [NIH ODS]. For most people, a single daily dose of this product is appropriate — but confirm with your healthcare provider first.
AI-assisted analysis. Data sourced from NIH DSLD.
Supplement Facts
| Brand | Major |
|---|---|
| Serving Size | |
| Contents | 100.0 Coated Caplet(s) |
| Market Status | On Market |
How to Read This Label
Supplement labels contain several key sections regulated by the FDA:
- Serving Size — The recommended amount per dose. Always check this — some products require multiple capsules per serving.
- Amount Per Serving — Shows the quantity of each nutrient in the product, typically in IU (International Units), mg (milligrams), or mcg (micrograms).
- % Daily Value (%DV) — Indicates how much a nutrient in a serving contributes to a daily diet. 5% DV or less is low; 20% DV or more is high.
- Other Ingredients — Lists inactive ingredients like fillers, binders, and capsule materials (e.g., gelatin, cellulose, magnesium stearate).
- Suggested Use — The manufacturer's recommended directions for taking the supplement, including timing and dosage.
Source: FDA Dietary Supplement Labeling Guide