21st Century Papaya Enzyme
Brand: 21st Century · Form: TABLET [E0155] On Market
Our assessment
The evidence shows that 21st Century Papaya Enzyme is a digestive supplement, but based on the data provided, the primary ingredient with clinical data is Calcium. For calcium, the data supports its role in bone mineralization and neuromuscular relaxation [NIH ODS]. However, we cannot assess the specific effectiveness of papaya enzyme itself because no studies or data on that ingredient were provided.
How it works
Calcium acts as a master regulator for your bones and muscles. It supports bone density through mineral deposition and helps your muscles relax and your nerves signal properly [NIH ODS]. For the papaya enzyme component, specific mechanism data is not available.
Safety profile
FDA received a total of 592,059 adverse event reports across all supplements. For calcium specifically, side effects from very high intakes include constipation, nausea, weight loss, extreme tiredness, frequent urination, and abnormal heart rhythms [NIH ODS]. High calcium levels can also lead to poor kidney function and a high risk of death from heart disease [NIH ODS]. Calcium can reduce absorption of medications including bisphosphonates, tetracycline antibiotics, fluoroquinolone antibiotics, levothyroxine, and phenytoin [NIH ODS].
Our recommendation
For general digestive support, we cannot recommend this product based on the data provided, as no studies on papaya enzyme were included. If you are taking this for calcium, be aware that most adults meet their calcium needs through diet. The data shows that high calcium intakes may increase the risk of heart disease and prostate cancer [NIH ODS]. Always separate calcium supplements from your thyroid or antibiotic medications by at least 2 hours [NIH ODS]. Consult your doctor before starting any new supplement.
AI-assisted analysis. Data sourced from NIH DSLD.
Supplement Facts
| Brand | 21st Century |
|---|---|
| Serving Size | |
| Contents | 100.0 Tablet(s) |
| Market Status | On Market |
How to Read This Label
Supplement labels contain several key sections regulated by the FDA:
- Serving Size — The recommended amount per dose. Always check this — some products require multiple capsules per serving.
- Amount Per Serving — Shows the quantity of each nutrient in the product, typically in IU (International Units), mg (milligrams), or mcg (micrograms).
- % Daily Value (%DV) — Indicates how much a nutrient in a serving contributes to a daily diet. 5% DV or less is low; 20% DV or more is high.
- Other Ingredients — Lists inactive ingredients like fillers, binders, and capsule materials (e.g., gelatin, cellulose, magnesium stearate).
- Suggested Use — The manufacturer's recommended directions for taking the supplement, including timing and dosage.
Source: FDA Dietary Supplement Labeling Guide