The Vitamin Shoppe Magnesium Glycinate 400 mg

Our assessment

The evidence shows that magnesium glycinate is a well-absorbed form of magnesium often used to support relaxation and muscle function. For this specific product, the data on the exact formulation and purity is not available in the provided information. Without specific laboratory analysis from the manufacturer in this data set, we cannot verify the actual 400 mg claim per serving. Our general clinical assessment is that magnesium glycinate is a high-quality form, but we rely on the provided data for this specific product.

How it works

Magnesium is an essential mineral that acts as a cofactor in over 300 enzyme systems. These reactions are critical for energy production, muscle contraction, nerve function, and maintaining a healthy heartbeat [NIH ODS]. The “glycinate” form means magnesium is bound to the amino acid glycine, which may improve absorption and reduce the likelihood of digestive side effects compared to other forms like magnesium oxide. You can think of magnesium as a calming mineral that helps regulate your nervous system and support restful sleep [NIH ODS].

Safety profile

Based on the provided data, specific adverse event reports for this exact product are not available. General safety data from the FDA shows that magnesium supplements are well-tolerated, but high doses can cause side effects. The data provided does not include specific report counts for this product. [FDA data] The National Institutes of Health Office of Dietary Supplements notes that very high intakes of magnesium from non-food sources can lead to diarrhea, nausea, and abdominal cramping [NIH ODS]. For this specific 400 mg product, it is important to stay within the tolerable upper intake level from supplements, which is 350 mg per day for adults [NIH ODS].

Our recommendation

For this specific product, start with one capsule daily and assess your tolerance. Because the upper limit from supplements is 350 mg, taking two capsules (800 mg) would exceed that threshold and may cause loose stools [NIH ODS]. We recommend taking it with food to minimize any potential stomach upset. Always consult your physician before starting a new supplement, especially if you have kidney disease or are taking medications like diuretics or antibiotics [NIH ODS].

Supplement labels contain several key sections regulated by the FDA:

• Serving Size — The recommended amount per dose. Always check this — some products require multiple capsules per serving.
• Amount Per Serving — Shows the quantity of each nutrient in the product, typically in IU (International Units), mg (milligrams), or mcg (micrograms).
• % Daily Value (%DV) — Indicates how much a nutrient in a serving contributes to a daily diet. 5% DV or less is low; 20% DV or more is high.
• Other Ingredients — Lists inactive ingredients like fillers, binders, and capsule materials (e.g., gelatin, cellulose, magnesium stearate).
• Suggested Use — The manufacturer's recommended directions for taking the supplement, including timing and dosage.

Source: FDA Dietary Supplement Labeling Guide