Metagenics St. John's Wort with Folate and B12
Brand: Metagenics · Form: TABLET [E0155] On Market
Our assessment
Our assessment: The evidence for this specific combination product is limited. While St. John's Wort is used for mood support, and folate with B12 supports nerve function, the data provided does not include specific studies on this exact formulation. The calcium in this product may pose risks, with some research suggesting that high calcium intakes might increase the risk of heart disease and prostate cancer [NIH ODS].
How it works
Think of this product as combining three different mechanisms. St. John's Wort is traditionally used to support mood. Folate and vitamin B12 work together to support nerve health and red blood cell formation. The calcium in this formula supports bone mineralization and neuromuscular relaxation, helping your bones stay dense and your muscles relax and signal properly [NIH ODS].
Safety profile
Data not available for adverse events specific to this product. The broader FDA database contains 592,059 total adverse event reports across all supplements, but no breakdown for this combination is provided [FDA data]. For the calcium component, high levels in the blood and urine can cause poor muscle tone, poor kidney function, low phosphate levels, constipation, nausea, weight loss, extreme tiredness, frequent need to urinate, abnormal heart rhythms, and a high risk of death from heart disease [NIH ODS].
Our recommendation
We recommend caution. Calcium can reduce the absorption of several medications, including bisphosphonates, tetracycline antibiotics, fluoroquinolone antibiotics, levothyroxine, and phenytoin [NIH ODS]. If you take any of these medications, consult your doctor before using this product. Without specific safety data for the St. John's Wort and B-vitamin combination, we cannot recommend this for everyday use.
AI-assisted analysis. Data sourced from NIH DSLD.
Supplement Facts
| Brand | Metagenics |
|---|---|
| Serving Size | |
| Contents | 60.0 Tablet(s) |
| Market Status | On Market |
How to Read This Label
Supplement labels contain several key sections regulated by the FDA:
- Serving Size — The recommended amount per dose. Always check this — some products require multiple capsules per serving.
- Amount Per Serving — Shows the quantity of each nutrient in the product, typically in IU (International Units), mg (milligrams), or mcg (micrograms).
- % Daily Value (%DV) — Indicates how much a nutrient in a serving contributes to a daily diet. 5% DV or less is low; 20% DV or more is high.
- Other Ingredients — Lists inactive ingredients like fillers, binders, and capsule materials (e.g., gelatin, cellulose, magnesium stearate).
- Suggested Use — The manufacturer's recommended directions for taking the supplement, including timing and dosage.
Source: FDA Dietary Supplement Labeling Guide