Metagenics Intrinsi B12-Folate
Brand: Metagenics · Form: TABLET [E0155] On Market
Our assessment
The evidence shows that Metagenics Intrinsi B12-Folate is a specialty supplement designed to support vitamin B12 and folate status. While the specific formula is unique, the core ingredients are well-studied. Data on the individual ingredient calcium is available, but specific trial data for this exact combination product is limited.
How it works
Think of calcium as a structural key for your body. It supports bone density and mineral deposition, which is essential for maintaining strong bones. Additionally, calcium plays a role in neuromuscular relaxation, helping your muscles relax and your nerves signal properly [NIH ODS].
Safety profile
FDA received a total of 592,059 adverse event reports across all supplements. For calcium specifically, safety data indicates that high intakes might increase the risk of heart disease and prostate cancer. High levels of calcium in the blood and urine can cause poor muscle tone, poor kidney function, low phosphate levels, constipation, nausea, weight loss, extreme tiredness, frequent need to urinate, abnormal heart rhythms, and a high risk of death from heart disease [FDA data] [NIH ODS]. Calcium can also reduce the absorption of several medications, including bisphosphonates, tetracycline antibiotics, fluoroquinolone antibiotics, levothyroxine, and phenytoin [NIH ODS].
Our recommendation
Our recommendation: Use this product only if you have a confirmed need for B12 and folate support, as directed by your healthcare provider. Be cautious about your total calcium intake from all sources (diet and supplements) to avoid exceeding safe upper limits. Always take calcium supplements at a different time than medications like thyroid hormone or antibiotics to prevent absorption issues [NIH ODS].
AI-assisted analysis. Data sourced from NIH DSLD.
Supplement Facts
| Brand | Metagenics |
|---|---|
| Serving Size | |
| Contents | 60.0 Tablet(s) |
| Market Status | On Market |
How to Read This Label
Supplement labels contain several key sections regulated by the FDA:
- Serving Size — The recommended amount per dose. Always check this — some products require multiple capsules per serving.
- Amount Per Serving — Shows the quantity of each nutrient in the product, typically in IU (International Units), mg (milligrams), or mcg (micrograms).
- % Daily Value (%DV) — Indicates how much a nutrient in a serving contributes to a daily diet. 5% DV or less is low; 20% DV or more is high.
- Other Ingredients — Lists inactive ingredients like fillers, binders, and capsule materials (e.g., gelatin, cellulose, magnesium stearate).
- Suggested Use — The manufacturer's recommended directions for taking the supplement, including timing and dosage.
Source: FDA Dietary Supplement Labeling Guide