Premier Research Labs Melatonin-ND
Brand: Premier Research Labs · Form: LIQUID, SUPPLEMENT FORM [E0165] On Market
Our assessment
Our assessment: The evidence on calcium is clear and well-established. For most adults, calcium is essential for maintaining strong bones and supporting proper muscle and nerve function. However, the data shows you need to be careful with dosing — high intakes carry real risks, and the supplement is not for everyone. We recommend getting your calcium from food first and using supplements only if a healthcare provider confirms you need them.
How it works
Think of calcium as a structural building block for your skeleton. It supports bone density and mineral deposition — essentially, it helps keep your bones hard and strong [NIH ODS]. Calcium also plays a key role in neuromuscular relaxation, meaning it helps your muscles relax after contracting and supports proper nerve signaling throughout your body [NIH ODS].
Safety profile
The FDA has received a total of 592,059 adverse event reports for this product category. The data shows that high calcium intakes might increase the risk of heart disease and prostate cancer [NIH ODS]. Very high levels of calcium in your blood and urine can cause poor muscle tone, poor kidney function, low phosphate levels, constipation, nausea, weight loss, extreme tiredness, frequent need to urinate, abnormal heart rhythms, and a high risk of death from heart disease [NIH ODS]. Additionally, calcium can reduce the absorption of several medications, including bisphosphonates, tetracycline antibiotics, fluoroquinolone antibiotics, levothyroxine, and phenytoin [NIH ODS].
Our recommendation
Our recommendation: Do not take calcium supplements unless a doctor has confirmed you have a deficiency or cannot meet your needs through diet. If you do need a supplement, start with a low dose and take it with food. Be aware that calcium can interfere with many common medications — take it at a different time of day from your prescriptions [NIH ODS]. Data not available for this specific product's exact dose or form.
AI-assisted analysis. Data sourced from NIH DSLD.
Supplement Facts
| Brand | Premier Research Labs |
|---|---|
| Serving Size | |
| Contents | 2.0 Fluid Ounce(s) 54.0 mL |
| Market Status | On Market |
How to Read This Label
Supplement labels contain several key sections regulated by the FDA:
- Serving Size — The recommended amount per dose. Always check this — some products require multiple capsules per serving.
- Amount Per Serving — Shows the quantity of each nutrient in the product, typically in IU (International Units), mg (milligrams), or mcg (micrograms).
- % Daily Value (%DV) — Indicates how much a nutrient in a serving contributes to a daily diet. 5% DV or less is low; 20% DV or more is high.
- Other Ingredients — Lists inactive ingredients like fillers, binders, and capsule materials (e.g., gelatin, cellulose, magnesium stearate).
- Suggested Use — The manufacturer's recommended directions for taking the supplement, including timing and dosage.
Source: FDA Dietary Supplement Labeling Guide