NESS Nutritional Enzyme Support System Formula 6 G.I. Relief

Our assessment

The evidence shows that NESS Nutritional Enzyme Support System Formula 6 G.I. Relief contains calcium as an ingredient. For general health, calcium is essential for bone mineralization and neuromuscular relaxation [NIH ODS]. However, our assessment is that this specific formula’s effectiveness for gastrointestinal relief is not supported by the specific data provided here. You should be aware of the potential risks and interactions associated with calcium supplementation before using this product.

How it works

Calcium works in your body as a master regulator for two key functions. First, it supports bone density and mineral deposition through a process called bone mineralization [NIH ODS]. Second, it supports muscle relaxation and nerve signaling, which is known as neuromuscular relaxation [NIH ODS]. These processes are critical for everyday movement and nerve function.

Safety profile

The FDA has received a total of 592,059 adverse event reports for all dietary supplements, but specific report counts for this product or its calcium ingredient alone are not available. Side effects from high calcium intake can include constipation, nausea, weight loss, extreme tiredness, frequent need to urinate, and abnormal heart rhythms [NIH ODS]. Some research also suggests that high calcium intakes might increase the risk of heart disease and prostate cancer [NIH ODS]. Additionally, calcium can reduce the absorption of medications such as bisphosphonates, tetracycline antibiotics, fluoroquinolone antibiotics, levothyroxine, and phenytoin [NIH ODS].

Our recommendation

Do not take this product without first consulting your healthcare provider, especially if you take any prescription medications. Because calcium can interfere with the absorption of several common drugs, you must discuss timing and dosing with your doctor [NIH ODS]. If you are considering this supplement for gastrointestinal relief, note that the data provided does not support that specific use. A safer approach is to get your calcium needs assessed through a blood test and to rely on food sources first.

Supplement labels contain several key sections regulated by the FDA:

• Serving Size — The recommended amount per dose. Always check this — some products require multiple capsules per serving.
• Amount Per Serving — Shows the quantity of each nutrient in the product, typically in IU (International Units), mg (milligrams), or mcg (micrograms).
• % Daily Value (%DV) — Indicates how much a nutrient in a serving contributes to a daily diet. 5% DV or less is low; 20% DV or more is high.
• Other Ingredients — Lists inactive ingredients like fillers, binders, and capsule materials (e.g., gelatin, cellulose, magnesium stearate).
• Suggested Use — The manufacturer's recommended directions for taking the supplement, including timing and dosage.

Source: FDA Dietary Supplement Labeling Guide