NESS Nutritional Enzyme Support System Formula 701 Circulatory Support

Our assessment

The evidence shows that this product contains calcium, a mineral with established benefits for bone health. However, the data does not confirm that this specific formulation provides any unique advantage for circulatory support. You should be aware that high calcium intakes carry notable risks, and the data on this specific product’s effectiveness for circulation is not available.

How it works

Think of calcium as a structural building block for your bones and a signaling molecule for your muscles and nerves. It supports bone density and mineral deposition, and it plays a role in neuromuscular relaxation and nerve signaling [NIH ODS]. The specific mechanism by which this enzyme support system would aid circulatory function is not described in the data provided.

Safety profile

The FDA received a total of 592,059 adverse event reports for products in this category, though the data does not specify how many are linked to this exact formula [FDA data]. For calcium specifically, some research suggests that high intakes might increase the risk of heart disease and prostate cancer. High levels of calcium in the blood and urine can cause poor muscle tone, poor kidney function, low phosphate levels, constipation, nausea, weight loss, extreme tiredness, frequent need to urinate, abnormal heart rhythms, and a high risk of death from heart disease [NIH ODS]. Calcium can also reduce the absorption of several medications, including bisphosphonates, tetracycline antibiotics, fluoroquinolone antibiotics, levothyroxine, and phenytoin [NIH ODS].

Our recommendation

You should not take this supplement without consulting your healthcare provider, especially if you take any prescription medications. Given the potential for serious side effects from high calcium intake and the lack of specific data on circulatory benefits, we recommend focusing on getting your calcium from food sources and discussing any supplement use with your doctor or pharmacist [NIH ODS].

Supplement labels contain several key sections regulated by the FDA:

• Serving Size — The recommended amount per dose. Always check this — some products require multiple capsules per serving.
• Amount Per Serving — Shows the quantity of each nutrient in the product, typically in IU (International Units), mg (milligrams), or mcg (micrograms).
• % Daily Value (%DV) — Indicates how much a nutrient in a serving contributes to a daily diet. 5% DV or less is low; 20% DV or more is high.
• Other Ingredients — Lists inactive ingredients like fillers, binders, and capsule materials (e.g., gelatin, cellulose, magnesium stearate).
• Suggested Use — The manufacturer's recommended directions for taking the supplement, including timing and dosage.

Source: FDA Dietary Supplement Labeling Guide