EyePromise AREDS 2 Plus Zinc-Free

Our assessment

The evidence shows that EyePromise AREDS 2 Plus Zinc-Free is a specific formulation designed to support eye health by providing key nutrients found in the landmark Age-Related Eye Disease Study 2. Our assessment is that this product is suitable for individuals who need the AREDS 2 formula but must avoid zinc due to personal intolerance or medical advice. However, the data provided does not include specific clinical studies or dosage information for this exact product, so we must rely on general ingredient data.

How it works

One of the key ingredients in this formula is calcium, which plays a role in bone mineralization and neuromuscular relaxation, supporting bone density and nerve signaling [NIH ODS]. For eye health, the AREDS 2 formula typically works by providing antioxidants and minerals that may slow the progression of age-related macular degeneration. The specific mechanism of action for the complete formula is not detailed in the provided data.

Safety profile

FDA has received a total of 592,059 adverse event reports for all dietary supplements, but specific report counts for EyePromise AREDS 2 Plus Zinc-Free are not available [FDA data]. For the ingredient calcium, high intakes may increase the risk of heart disease and prostate cancer. Side effects from excessively high calcium levels can include poor muscle tone, poor kidney function, constipation, nausea, weight loss, extreme tiredness, and abnormal heart rhythms [NIH ODS]. Additionally, calcium can reduce the absorption of medications such as bisphosphonates, tetracycline antibiotics, and levothyroxine [NIH ODS].

Our recommendation

We recommend you consult with your eye doctor or primary care provider before starting this supplement, especially if you have a history of kidney stones, heart conditions, or are taking any prescription medications. Because this is a zinc-free formulation, it is best suited for those who cannot tolerate zinc. Do not take this product as a substitute for a balanced diet. Data not available for specific dosing or study outcomes for this exact branded product.

Supplement labels contain several key sections regulated by the FDA:

• Serving Size — The recommended amount per dose. Always check this — some products require multiple capsules per serving.
• Amount Per Serving — Shows the quantity of each nutrient in the product, typically in IU (International Units), mg (milligrams), or mcg (micrograms).
• % Daily Value (%DV) — Indicates how much a nutrient in a serving contributes to a daily diet. 5% DV or less is low; 20% DV or more is high.
• Other Ingredients — Lists inactive ingredients like fillers, binders, and capsule materials (e.g., gelatin, cellulose, magnesium stearate).
• Suggested Use — The manufacturer's recommended directions for taking the supplement, including timing and dosage.

Source: FDA Dietary Supplement Labeling Guide