Life Extension Optimized Folate L-Methylfolate 1700 mcg DFE
Brand: Life Extension · Form: TABLET [E0155] On Market
Our assessment
Our assessment: The evidence shows that Life Extension Optimized Folate L-Methylfolate 1700 mcg DFE provides a highly bioavailable form of folate. However, this specific product contains calcium as a key ingredient, and we must focus on the data we have. For calcium, the data supports its role in bone health, but you should be aware of important safety considerations. Data not available for the specific folate form's mechanism or side effects from the provided sources.
How it works
Think of calcium as a structural builder for your bones. It supports bone mineralization and density, and it also plays a role in neuromuscular relaxation and nerve signaling [NIH ODS]. This makes it essential for maintaining strong bones and proper muscle function.
Safety profile
Safety data is available for calcium, not the specific folate form. The FDA has received a total of 592,059 adverse event reports across all supplements, but specific counts for this product are not available. For calcium, high intakes might increase the risk of heart disease and prostate cancer. High blood levels can cause poor muscle tone, poor kidney function, constipation, nausea, weight loss, extreme tiredness, frequent urination, abnormal heart rhythms, and a high risk of death from heart disease [NIH ODS]. Calcium can also reduce the absorption of medications like bisphosphonates, tetracycline antibiotics, fluoroquinolone antibiotics, levothyroxine, and phenytoin [NIH ODS].
Our recommendation
Our recommendation: If you are taking this product for its folate content, be aware of the calcium it contains. Do not exceed the recommended daily intake for calcium from all sources (supplements and diet combined). If you take any medications listed above, separate your doses by at least 2 hours. Consult your doctor before starting this supplement, especially if you have a history of kidney stones, heart disease, or are on any prescription medications [NIH ODS].
AI-assisted analysis. Data sourced from NIH DSLD.
Supplement Facts
| Brand | Life Extension |
|---|---|
| Serving Size | |
| Contents | 100.0 Vegetarian Tablet(s) |
| Market Status | On Market |
How to Read This Label
Supplement labels contain several key sections regulated by the FDA:
- Serving Size — The recommended amount per dose. Always check this — some products require multiple capsules per serving.
- Amount Per Serving — Shows the quantity of each nutrient in the product, typically in IU (International Units), mg (milligrams), or mcg (micrograms).
- % Daily Value (%DV) — Indicates how much a nutrient in a serving contributes to a daily diet. 5% DV or less is low; 20% DV or more is high.
- Other Ingredients — Lists inactive ingredients like fillers, binders, and capsule materials (e.g., gelatin, cellulose, magnesium stearate).
- Suggested Use — The manufacturer's recommended directions for taking the supplement, including timing and dosage.
Source: FDA Dietary Supplement Labeling Guide