O Nutritions Advanced Collagen Peptides with Bioton Unflavored

Our assessment

The evidence shows that the calcium co-formulated in this product plays a critical role in bone health, but it also carries notable risks that you must consider. Our assessment is that while calcium is essential, you should not exceed the recommended intake from all sources, as the data links high intakes to serious health concerns [NIH ODS].

How it works

Think of calcium as a structural cornerstone for your skeleton. It supports bone density and mineral deposition, which is vital for maintaining strong bones as you age. Additionally, it supports neuromuscular relaxation, helping your muscles relax and your nerves signal properly after activity [NIH ODS].

Safety profile

The FDA has received a total of 592,059 adverse event reports across all supplements, though specific report counts for calcium alone are not available. However, the data on calcium is clear: high intakes might increase the risk of heart disease and prostate cancer. High levels in your blood and urine can cause poor muscle tone, poor kidney function, low phosphate levels, constipation, nausea, weight loss, extreme tiredness, frequent need to urinate, abnormal heart rhythms, and a high risk of death from heart disease [NIH ODS] [FDA data].

Our recommendation

We recommend that you assess your total daily calcium intake from both food and supplements. If you are already getting calcium from your diet, you likely do not need additional supplementation. Be aware that calcium can reduce the absorption of several medications, including bisphosphonates, tetracycline antibiotics, fluoroquinolone antibiotics, levothyroxine, and phenytoin [NIH ODS]. Data on the specific collagen and biotin content is not available, so we cannot comment on their effects.

Supplement labels contain several key sections regulated by the FDA:

• Serving Size — The recommended amount per dose. Always check this — some products require multiple capsules per serving.
• Amount Per Serving — Shows the quantity of each nutrient in the product, typically in IU (International Units), mg (milligrams), or mcg (micrograms).
• % Daily Value (%DV) — Indicates how much a nutrient in a serving contributes to a daily diet. 5% DV or less is low; 20% DV or more is high.
• Other Ingredients — Lists inactive ingredients like fillers, binders, and capsule materials (e.g., gelatin, cellulose, magnesium stearate).
• Suggested Use — The manufacturer's recommended directions for taking the supplement, including timing and dosage.

Source: FDA Dietary Supplement Labeling Guide