Applied Nutriceuticals Melatonin

Our assessment

The evidence shows that the product Applied Nutriceuticals Melatonin is labeled to contain calcium, but specific data for this product’s effects is limited. Based on the general data for calcium, calcium supports bone density and muscle relaxation [NIH ODS]. However, you should be aware that high calcium intakes may increase the risk of heart disease and prostate cancer [NIH ODS].

How it works

Think of calcium as a structural builder for your bones. It works through bone mineralization to support bone density and mineral deposition, and it also supports neuromuscular relaxation for proper muscle and nerve signaling [NIH ODS]. This means calcium helps keep your skeleton strong and your nerves communicating effectively.

Safety profile

Data not available for this specific product. However, for calcium in general, high levels in the blood and urine can cause poor muscle tone, poor kidney function, low phosphate levels, constipation, nausea, weight loss, extreme tiredness, frequent need to urinate, abnormal heart rhythms, and a high risk of death from heart disease [NIH ODS]. The FDA received a total of 592,059 adverse event reports across all supplements, but report counts specific to this product are not available [FDA data].

Our recommendation

Our assessment: Do not exceed recommended calcium intakes from supplements. Calcium can reduce the absorption of several medications, including bisphosphonates, tetracycline antibiotics, fluoroquinolone antibiotics, levothyroxine, and phenytoin [NIH ODS]. You should talk to your healthcare provider before adding this supplement, especially if you take any of those medications. Data not available for this product’s specific risks, so proceed with caution [NIH ODS].

Supplement labels contain several key sections regulated by the FDA:

• Serving Size — The recommended amount per dose. Always check this — some products require multiple capsules per serving.
• Amount Per Serving — Shows the quantity of each nutrient in the product, typically in IU (International Units), mg (milligrams), or mcg (micrograms).
• % Daily Value (%DV) — Indicates how much a nutrient in a serving contributes to a daily diet. 5% DV or less is low; 20% DV or more is high.
• Other Ingredients — Lists inactive ingredients like fillers, binders, and capsule materials (e.g., gelatin, cellulose, magnesium stearate).
• Suggested Use — The manufacturer's recommended directions for taking the supplement, including timing and dosage.

Source: FDA Dietary Supplement Labeling Guide