Natrol Melatonin Time Release 5 mg

Our assessment

The evidence shows that Natrol Melatonin Time Release 5 mg is a supplement designed to support sleep, but the specific data on melatonin itself is limited here. The product contains the ingredient calcium, which plays a role in bone mineralization and neuromuscular relaxation [NIH ODS]. However, for a sleep aid, you should know that the FDA has received 592,059 total adverse event reports across all supplements, though specific data for this product is not available [FDA data].

How it works

Think of calcium as a key player in your body's relaxation and signaling processes. It supports bone density and mineral deposition, and it helps with neuromuscular relaxation and nerve signaling [NIH ODS]. For the melatonin component, a time-release formulation is designed to provide a gradual release of melatonin overnight, but the specific mechanism data for melatonin is not provided in the available information.

Safety profile

Data on side effects for this specific product is not available. For the calcium ingredient, high levels in the blood and urine can cause poor muscle tone, poor kidney function, low phosphate levels, constipation, nausea, weight loss, extreme tiredness, frequent need to urinate, abnormal heart rhythms, and a high risk of death from heart disease [NIH ODS]. Some research also suggests high calcium intakes might increase the risk of heart disease and prostate cancer [NIH ODS]. Calcium can reduce the absorption of several medications, including bisphosphonates, tetracycline antibiotics, fluoroquinolone antibiotics, levothyroxine, and phenytoin [NIH ODS].

Our recommendation

Start by reviewing the product label for exact ingredients and dosage. Because the data does not provide specific safety or efficacy information for this melatonin product, we recommend consulting your healthcare provider before starting any new supplement. For sleep concerns, prioritize good sleep hygiene and discuss any underlying issues with your doctor. Data not available for a more specific recommendation on this product.

Supplement labels contain several key sections regulated by the FDA:

• Serving Size — The recommended amount per dose. Always check this — some products require multiple capsules per serving.
• Amount Per Serving — Shows the quantity of each nutrient in the product, typically in IU (International Units), mg (milligrams), or mcg (micrograms).
• % Daily Value (%DV) — Indicates how much a nutrient in a serving contributes to a daily diet. 5% DV or less is low; 20% DV or more is high.
• Other Ingredients — Lists inactive ingredients like fillers, binders, and capsule materials (e.g., gelatin, cellulose, magnesium stearate).
• Suggested Use — The manufacturer's recommended directions for taking the supplement, including timing and dosage.

Source: FDA Dietary Supplement Labeling Guide