Life Extension Super Omega-3

Our assessment

The evidence shows that calcium is a critical mineral for bone health, but supplementation requires careful consideration. For the general adult population, meeting the RDA through diet is often preferable to high-dose supplements, as some research suggests high calcium intakes might increase the risk of heart disease and prostate cancer [NIH ODS].

How it works

Think of calcium as a structural builder and a cellular messenger. It supports bone mineralization and density, while also helping your muscles relax and your nerves signal properly [NIH ODS]. Getting the right amount is key — too little weakens bones, but too much may create other risks.

Safety profile

FDA has received 592,059 total adverse event reports across all supplements, though specific data for calcium alone is not available. You should be aware that high levels of calcium in the blood and urine can cause poor muscle tone, poor kidney function, low phosphate levels, constipation, nausea, weight loss, extreme tiredness, frequent need to urinate, abnormal heart rhythms, and a high risk of death from heart disease [NIH ODS]. Calcium can also reduce the absorption of several medications, including bisphosphonates, tetracycline antibiotics, fluoroquinolone antibiotics, levothyroxine, and phenytoin [NIH ODS].

Our recommendation

Start by assessing your dietary calcium intake from food sources like dairy, leafy greens, and fortified foods. If you fall short, consider a modest supplement — typically 500–600 mg daily — and take it with food for better absorption. Always separate calcium supplements from thyroid medication or antibiotics by at least 4 hours to avoid interactions [NIH ODS]. Consult your doctor before starting, especially if you have a history of kidney stones or heart conditions.

Supplement labels contain several key sections regulated by the FDA:

• Serving Size — The recommended amount per dose. Always check this — some products require multiple capsules per serving.
• Amount Per Serving — Shows the quantity of each nutrient in the product, typically in IU (International Units), mg (milligrams), or mcg (micrograms).
• % Daily Value (%DV) — Indicates how much a nutrient in a serving contributes to a daily diet. 5% DV or less is low; 20% DV or more is high.
• Other Ingredients — Lists inactive ingredients like fillers, binders, and capsule materials (e.g., gelatin, cellulose, magnesium stearate).
• Suggested Use — The manufacturer's recommended directions for taking the supplement, including timing and dosage.

Source: FDA Dietary Supplement Labeling Guide