NESS Nutritional Enzyme Support System Formula 301 Sinus Support

Our assessment

The evidence shows that NESS Nutritional Enzyme Support System Formula 301 Sinus Support contains calcium as an active ingredient. Our assessment is that the calcium in this product may support bone mineralization and neuromuscular relaxation, but you should be aware of important safety considerations before using it [NIH ODS].

How it works

Think of calcium as a critical mineral for your body. It supports bone density through a process called bone mineralization, where calcium is deposited into your skeleton. Calcium also plays a role in neuromuscular relaxation, helping your muscles and nerves signal properly [NIH ODS].

Safety profile

Data not available for specific adverse events for this product. However, for the ingredient calcium, some research suggests that high intakes might increase the risk of heart disease and prostate cancer [NIH ODS]. High levels of calcium in the blood and urine can cause poor muscle tone, poor kidney function, low phosphate levels, constipation, nausea, weight loss, extreme tiredness, frequent need to urinate, abnormal heart rhythms, and a high risk of death from heart disease [NIH ODS]. The FDA has received a total of 592,059 adverse event reports across all dietary supplements, but specific report counts for this product are not available [FDA data].

Our recommendation

We recommend that you consult with your healthcare provider before using this supplement, especially if you take medications such as bisphosphonates, tetracycline antibiotics, fluoroquinolone antibiotics, levothyroxine, or phenytoin, as calcium can reduce their absorption [NIH ODS]. Start with a low dose and monitor for any side effects. If you experience symptoms like constipation, nausea, or extreme tiredness, discontinue use and speak with your doctor [NIH ODS].

Supplement labels contain several key sections regulated by the FDA:

• Serving Size — The recommended amount per dose. Always check this — some products require multiple capsules per serving.
• Amount Per Serving — Shows the quantity of each nutrient in the product, typically in IU (International Units), mg (milligrams), or mcg (micrograms).
• % Daily Value (%DV) — Indicates how much a nutrient in a serving contributes to a daily diet. 5% DV or less is low; 20% DV or more is high.
• Other Ingredients — Lists inactive ingredients like fillers, binders, and capsule materials (e.g., gelatin, cellulose, magnesium stearate).
• Suggested Use — The manufacturer's recommended directions for taking the supplement, including timing and dosage.

Source: FDA Dietary Supplement Labeling Guide