Natrol Advanced Sleep Melatonin + 5-HTP
Brand: Natrol · Form: TABLET [E0155]
Our assessment
The evidence shows that this product combines two well-studied ingredients, melatonin and 5-HTP, for sleep support. However, the data available for the individual ingredients is limited in scope. Our assessment is that you should approach this combination with caution, as safety data for the specific blend is not provided. Data not available.
How it works
Calcium, one of the ingredients listed in the supporting data, functions as a master regulator for bone mineralization and neuromuscular relaxation, which supports nerve signaling and muscle function [NIH ODS]. The product's intended purpose for sleep is likely driven by the melatonin and 5-HTP components, but specific mechanisms for this combination are not provided in the data.
Safety profile
FDA received 592,059 total adverse event reports for all supplements, though the specific number for this product is not available [FDA data]. For the ingredient calcium, high intakes can cause constipation, nausea, weight loss, extreme tiredness, frequent need to urinate, abnormal heart rhythms, and a high risk of death from heart disease [NIH ODS]. Calcium can also reduce the absorption of several medications, including bisphosphonates, tetracycline antibiotics, fluoroquinolone antibiotics, levothyroxine, and phenytoin [NIH ODS].
Our recommendation
We recommend you start with a single-ingredient sleep supplement to better understand your body's response. Given the potential interactions and side effects, consult your doctor before using this product, especially if you take any prescription medications. Data not available for the specific safety of the melatonin and 5-HTP combination in this product.
AI-assisted analysis. Data sourced from NIH DSLD.
Supplement Facts
| Brand | Natrol |
|---|---|
| Serving Size | |
| Contents | 60.0 Bi-Layer Tablet(s) |
| Market Status | Off Market |
How to Read This Label
Supplement labels contain several key sections regulated by the FDA:
- Serving Size — The recommended amount per dose. Always check this — some products require multiple capsules per serving.
- Amount Per Serving — Shows the quantity of each nutrient in the product, typically in IU (International Units), mg (milligrams), or mcg (micrograms).
- % Daily Value (%DV) — Indicates how much a nutrient in a serving contributes to a daily diet. 5% DV or less is low; 20% DV or more is high.
- Other Ingredients — Lists inactive ingredients like fillers, binders, and capsule materials (e.g., gelatin, cellulose, magnesium stearate).
- Suggested Use — The manufacturer's recommended directions for taking the supplement, including timing and dosage.
Source: FDA Dietary Supplement Labeling Guide