Dietary Supplement Interventions and Sleep Quality Improvement: A Systematic Review and Meta-Analysis.

Our assessment

A 2025 systematic review and meta-analysis examined whether dietary supplements can improve sleep quality. The study pooled data from multiple trials to look for overall patterns. Because the abstract provided does not specify the exact number of participants or the duration of the studies, these details are not available. This is a comprehensive review of existing research, but without the full sample size, it is difficult to assess the strength of the evidence. What this means for you: A review like this combines many smaller studies to find a general trend, but the quality of that trend depends on the individual studies included. Data not available NIH ODS ↗ NIH DSLD ↗.

How it works

The researchers looked at how different dietary supplements might act as a master regulator for sleep. The idea is that certain nutrients can support the body's natural sleep-wake cycle, potentially helping you fall asleep faster or stay asleep longer. The review focused on dietary supplement interventions, meaning any pill, powder, or extract taken to improve sleep quality. What this means for you: If you are struggling with sleep, the review suggests that supplementing with specific nutrients might be an option, but it does not identify which ones worked best. Data not available NIH ODS ↗ FDA FAERS ↗.

Safety profile

Specific side effects and adverse event reports from the FDA are not included in the provided data for this review. The abstract does not list any safety information or report counts for side effects. What this means for you: Without this data, we cannot speak to the safety of any specific supplement for sleep. Always talk to a doctor before starting a new supplement regimen. Data not available FDA FAERS ↗.

Our recommendation

Based on the data provided, we cannot make a specific recommendation for any one supplement. The review confirms that researchers are actively studying this topic, but the key findings are not detailed enough to guide personal use. What this means for you: Focus on foundational sleep hygiene first — consistent bedtimes, a dark and cool room, and limiting screen time before bed. If you are considering a supplement for sleep, consult your healthcare provider for personalized advice. Data not available NIH ODS ↗ NIH DSLD ↗.