Evaluation of a multi-component dietary supplement combined with probiotic and omega-3 in individuals with self-reported symptoms of brain fog: an 8-week exploratory study.

Our assessment

This exploratory study tested a multi-component dietary supplement combined with a probiotic and omega-3 in 39 participants who reported symptoms of brain fog. The study used an open-label, one-arm design, meaning everyone received the supplement and there was no placebo group. The trial lasted 8 weeks. Because the study included fewer than 100 participants, it is considered a small study, and results should be viewed as preliminary NIH ODS ↗. The primary measure was the change from baseline in survey scores of the Montreal Cognitive Assessment NIH ODS ↗.

How it works

Participants who took the supplement showed an improvement in their Montreal Cognitive Assessment scores over the 8-week period. What this means for you: the combination of ingredients in this supplement was associated with better cognitive test performance in people with self-reported brain fog. However, because this was a small, open-label study with no placebo group, it is not possible to say whether the supplement caused the improvement or if other factors were responsible NIH ODS ↗.

Safety profile

Data on side effects from this study is not available. No adverse event report counts were provided in the data for this specific supplement combination FDA FAERS ↗.

Our recommendation

Talk to your doctor before trying any new supplement for brain fog. While the study showed promising results in a small group, the open-label design and lack of a control group mean the findings are not conclusive. More research with larger groups and placebo controls is needed before any firm recommendations can be made NIH ODS ↗.