Dietary supplement considerations during glucagon-like Peptide-1 receptor agonist treatment: A narrative review.

Our assessment

This is a narrative review published in 2025 that examines the role of dietary supplements for people taking GLP-1 receptor agonists (GLP-1 RAs), a class of medications that can lead to approximately 15% or more weight reduction. The researchers reviewed emerging scientific evidence to address specific nutritional concerns, noting that current guidelines focus mainly on managing side effects and basic dietary advice. Because this is a narrative review, it summarizes existing research rather than conducting a new experiment with participants, so no sample size or study duration is available. Data not available on the exact number of studies included.

How it works

GLP-1 RAs help with significant weight loss, but they can also change how your body absorbs nutrients. This review highlights that people on these medications may need to pay special attention to their diet to avoid nutritional gaps. What this means for you: if you are taking a GLP-1 RA, you might benefit from discussing supplement use with your healthcare provider, especially since the medications reduce appetite and food intake, which could lead to lower levels of key vitamins and minerals. The review aims to provide practical, evidence-based guidance for supplement considerations during treatment NIH ODS ↗.

Safety profile

Data not available on adverse event reports specific to this review. The review focuses on nutritional considerations rather than side effects of the medications themselves. For general safety information about GLP-1 RAs, consult your healthcare provider. Data not available from FDA data for this specific review.

Our recommendation

If you are taking a GLP-1 RA for weight management, talk to your doctor about whether you need a multivitamin or specific supplements to cover potential nutrient shortfalls from reduced food intake. The review suggests that personalized, evidence-based supplement plans may be helpful, but more research is needed. Do not start any new supplement without medical guidance, as interactions are possible. Data not available on specific dosage recommendations from this review NIH DSLD ↗.