Effects of a Novel Prebiotic and Postbiotic Dietary Supplement on Gut Microbiota, Intestinal Barrier Markers, and Inflammation in Healthy Dogs.

Our assessment

Researchers studied a new combined prebiotic and postbiotic supplement in healthy dogs. The study was a randomized controlled trial involving 36 healthy adult dogs. The dogs were split into two groups: a control group (CON) that received a high-protein basal diet with a placebo chew, and a treatment group (TRT) that received the same basal diet but with a chew containing prebiotics (baobab fruit pulp and acacia gum) and postbiotics. The study was published in 2026. Because the total sample size is 36, this is considered a small study, which means results should be interpreted with caution.

How it works

The supplement was designed to support gastrointestinal health by influencing the gut microbiota, strengthening the intestinal barrier, and reducing inflammation. Think of the gut as a gatekeeper — prebiotics and postbiotics help feed good bacteria and support the lining of the gut wall, which can keep unwanted particles from entering the bloodstream. For your dog, this might mean better digestion and overall health during a dietary transition. The study specifically looked at markers for gut bacteria, intestinal barrier function, and inflammation.

Safety profile

Data not available. No specific side effects or adverse event report counts from the FDA were provided in the data for this supplement in dogs. The provided data does not include any FDA adverse event reports for this specific product.

Our recommendation

This single small study suggests a potential benefit for a combined prebiotic and postbiotic supplement during a diet change in healthy dogs. However, with only 36 dogs in the study, more research is needed to confirm these findings. Do not start any new supplement for your dog without first consulting your veterinarian.