Trends and determinants of dietary supplement use and potential drug- supplement interactions in older adults: a 16-years follow-up in the Tehran lipid and glucose study.

Our assessment

This study examined trends in dietary supplement use among older adults over a 16-year period. Researchers analyzed data from the Tehran Lipid and Glucose Study, a repeated cross-sectional survey that looked at adults aged 50 years and older across five examination periods: 2006–2008 (3,484 participants), 2009–2011 (4,020 participants), 2012–2014 (4,342 participants), 2015–2017 (4,598 participants), and 2018–2022 (4,750 participants) NIH ODS ↗. The study aimed to identify what factors influence supplement use and how often supplements might interact with prescription medications. This is a large, long-term study, which makes its findings reliable for tracking population trends.

How it works

The study found that dietary supplement use among older adults changed over the 16-year period. The researchers also identified specific factors that predicted supplement use and calculated the prevalence of potential drug-supplement interactions. What this means for you is that as you age, the likelihood of taking a supplement that could interact with your medications increases. The study highlights the importance of reviewing your full supplement and medication list with a healthcare provider, especially if you are over 50 and take multiple prescriptions NIH ODS ↗.

Safety profile

Data not available. The provided study abstract does not include specific side effect data or adverse event report counts for individual supplements. For safety information on specific supplements, refer to FDA adverse event reports and the NIH Office of Dietary Supplements fact sheets FDA FAERS ↗ NIH ODS ↗.

Our recommendation

This study underscores the need for older adults to be cautious about potential interactions between supplements and medications. Before starting any new supplement, discuss it with your doctor or pharmacist, especially if you are managing a chronic condition. A periodic "brown bag" review—bringing all your medications and supplements to an appointment—can help identify potential risks. This is a practical step to ensure your supplement routine is safe and appropriate for your health needs NIH ODS ↗.