Thorne 5-MTHF 1 mg
Brand: Thorne · Form: CAPSULE [E0159] On Market
Our assessment
Our assessment: Thorne 5-MTHF 1 mg provides a highly bioavailable form of folate. This is the active form your body can use immediately, unlike folic acid which requires conversion. For most adults, 1 mg (1,000 mcg) is a significant dose that supports methylation and red blood cell formation [NIH ODS].
How it works
Think of 5-MTHF (5-methyltetrahydrofolate) as a ready-to-work cofactor — it plays a direct role in converting homocysteine to methionine, a process vital for cardiovascular and neurological health [NIH ODS]. Because it is already in its active form, you do not need the MTHFR enzyme to process it, which is beneficial for people with common genetic variations that impair folate metabolism [NIH ODS].
Safety profile
Data not available for Thorne 5-MTHF 1 mg specifically. The FDA data provided does not include specific adverse event reports for this product. In general, high folate intake can mask a vitamin B12 deficiency, so ensure adequate B12 status when taking this supplement [NIH ODS].
Our recommendation
If you have an MTHFR mutation or need targeted folate support, this is a reliable choice. Start with the 1 mg dose and monitor your homocysteine levels with your healthcare provider. Do not exceed this amount without medical supervision, as the Tolerable Upper Intake Level for folic acid from supplements is 1,000 mcg daily [NIH ODS].
AI-assisted analysis. Data sourced from NIH DSLD.
Supplement Facts
| Brand | Thorne |
|---|---|
| Serving Size | |
| Contents | 60.0 Capsule(s) |
| Market Status | On Market |
How to Read This Label
Supplement labels contain several key sections regulated by the FDA:
- Serving Size — The recommended amount per dose. Always check this — some products require multiple capsules per serving.
- Amount Per Serving — Shows the quantity of each nutrient in the product, typically in IU (International Units), mg (milligrams), or mcg (micrograms).
- % Daily Value (%DV) — Indicates how much a nutrient in a serving contributes to a daily diet. 5% DV or less is low; 20% DV or more is high.
- Other Ingredients — Lists inactive ingredients like fillers, binders, and capsule materials (e.g., gelatin, cellulose, magnesium stearate).
- Suggested Use — The manufacturer's recommended directions for taking the supplement, including timing and dosage.
Source: FDA Dietary Supplement Labeling Guide