AOR Advanced Orthomolecular Research Premium Hydroxy B12 - 1mg

Our assessment

The evidence shows that this product contains calcium, a mineral essential for bone health. However, the data on calcium supplementation is mixed and requires careful consideration. For most adults, getting calcium from food sources is preferable to taking high-dose supplements [NIH ODS]. You should not take this supplement without first evaluating your dietary intake and discussing it with your healthcare provider.

How it works

Calcium is a master regulator for your body. It supports bone mineralization and density, and it is critical for neuromuscular relaxation and proper nerve signaling [NIH ODS]. Think of it as the key building block for your skeleton and a vital component for how your muscles and nerves communicate.

Safety profile

The FDA has received 592,059 total adverse event reports across all supplements, though specific report counts for calcium alone are not available in the provided data. Key safety concerns from the data include: high calcium intakes might increase the risk of heart disease and prostate cancer. Very high levels can cause poor muscle tone, poor kidney function, low phosphate levels, constipation, nausea, weight loss, extreme tiredness, frequent urination, abnormal heart rhythms, and a high risk of death from heart disease [NIH ODS]. Calcium can also reduce the absorption of several medications, including bisphosphonates, tetracycline antibiotics, fluoroquinolone antibiotics, levothyroxine, and phenytoin [NIH ODS].

Our recommendation

Data not available for a specific dosage recommendation for this product. You should prioritize getting calcium from dietary sources like dairy, leafy greens, and fortified foods. If you are considering this supplement, consult your doctor to determine if you have a true deficiency. Be aware of the potential for interactions with your medications and the risks associated with high intake [NIH ODS].

Supplement labels contain several key sections regulated by the FDA:

• Serving Size — The recommended amount per dose. Always check this — some products require multiple capsules per serving.
• Amount Per Serving — Shows the quantity of each nutrient in the product, typically in IU (International Units), mg (milligrams), or mcg (micrograms).
• % Daily Value (%DV) — Indicates how much a nutrient in a serving contributes to a daily diet. 5% DV or less is low; 20% DV or more is high.
• Other Ingredients — Lists inactive ingredients like fillers, binders, and capsule materials (e.g., gelatin, cellulose, magnesium stearate).
• Suggested Use — The manufacturer's recommended directions for taking the supplement, including timing and dosage.

Source: FDA Dietary Supplement Labeling Guide