Cardiovascular Research Oncotonin Liposomal Melatonin 10 mg

Our assessment

The evidence shows that this product contains 10 mg of melatonin per serving, but the most robust data available relates to its calcium content. Calcium is essential for bone mineralization and neuromuscular relaxation [NIH ODS]. For a general audience, we would not recommend starting with a 10 mg melatonin dose without first consulting your healthcare provider, as this is a high dose. Data not available on the specific effects of the "Oncotonin" or "Liposomal" delivery system.

How it works

Think of calcium as a master regulator for your bones and muscles. It supports bone density through mineral deposition and helps your muscles relax and your nerves send signals properly [NIH ODS]. The "liposomal" label suggests the manufacturer intends to improve absorption, but no specific data on this formulation is available. Melatonin typically helps regulate sleep-wake cycles, though specific data on this product's mechanism is not provided.

Safety profile

FDA received 592,059 total adverse event reports for all products, but specific reports for this brand are not listed. For calcium, high intakes might increase the risk of heart disease and prostate cancer [NIH ODS]. Side effects from high calcium levels include poor muscle tone, poor kidney function, low phosphate levels, constipation, nausea, weight loss, extreme tiredness, frequent need to urinate, abnormal heart rhythms, and a high risk of death from heart disease [NIH ODS]. Calcium can reduce the absorption of bisphosphonates, tetracycline antibiotics, fluoroquinolone antibiotics, levothyroxine, and phenytoin [NIH ODS].

Our recommendation

We recommend you avoid this product unless specifically directed by your physician. The 10 mg melatonin dose is high, and the safety data for the combined formulation is not provided. For calcium, do not exceed the tolerable upper intake level without medical supervision. If you take any medications listed in the interactions, take calcium supplements at least 2 hours apart [NIH ODS]. Always consult your pharmacist or doctor before starting a new supplement, especially one with multiple active ingredients at significant doses.

Supplement labels contain several key sections regulated by the FDA:

• Serving Size — The recommended amount per dose. Always check this — some products require multiple capsules per serving.
• Amount Per Serving — Shows the quantity of each nutrient in the product, typically in IU (International Units), mg (milligrams), or mcg (micrograms).
• % Daily Value (%DV) — Indicates how much a nutrient in a serving contributes to a daily diet. 5% DV or less is low; 20% DV or more is high.
• Other Ingredients — Lists inactive ingredients like fillers, binders, and capsule materials (e.g., gelatin, cellulose, magnesium stearate).
• Suggested Use — The manufacturer's recommended directions for taking the supplement, including timing and dosage.

Source: FDA Dietary Supplement Labeling Guide