Priority One Nutritional Supplements Folate Methylation
Brand: Priority One Nutritional Supplements · Form: CAPSULE [E0159] On Market
Our assessment
The evidence shows that the active ingredient in this supplement, calcium, has a well-established role in supporting bone health, but the data on its benefits for "methylation" is not available. Our primary focus is on the calcium content and its known effects [NIH ODS].
How it works
Think of calcium as a structural and signaling mineral. It supports bone mineralization and density, and it is critical for neuromuscular relaxation and nerve signaling. These mechanisms are independent of any folate methylation pathway, for which data is not available [NIH ODS].
Safety profile
FDA received 592,059 adverse event reports for this product category. Based on data for calcium, high intakes might increase the risk of heart disease and prostate cancer. High blood and urine levels of calcium can cause poor muscle tone, poor kidney function, low phosphate levels, constipation, nausea, weight loss, extreme tiredness, frequent need to urinate, abnormal heart rhythms, and a high risk of death from heart disease [FDA data] [NIH ODS].
Our recommendation
If you are considering this supplement for methylation support, the data does not support that claim. For calcium, you should not exceed the recommended dietary allowance without medical supervision. Be aware that calcium can reduce the absorption of medications like bisphosphonates, tetracycline antibiotics, fluoroquinolone antibiotics, levothyroxine, and phenytoin [NIH ODS]. Consult your healthcare provider before starting this product.
AI-assisted analysis. Data sourced from NIH DSLD.
Supplement Facts
| Brand | Priority One Nutritional Supplements |
|---|---|
| Serving Size | |
| Contents | 60.0 Vegetarian Capsule(s) |
| Market Status | On Market |
How to Read This Label
Supplement labels contain several key sections regulated by the FDA:
- Serving Size — The recommended amount per dose. Always check this — some products require multiple capsules per serving.
- Amount Per Serving — Shows the quantity of each nutrient in the product, typically in IU (International Units), mg (milligrams), or mcg (micrograms).
- % Daily Value (%DV) — Indicates how much a nutrient in a serving contributes to a daily diet. 5% DV or less is low; 20% DV or more is high.
- Other Ingredients — Lists inactive ingredients like fillers, binders, and capsule materials (e.g., gelatin, cellulose, magnesium stearate).
- Suggested Use — The manufacturer's recommended directions for taking the supplement, including timing and dosage.
Source: FDA Dietary Supplement Labeling Guide