ProThera Melatonin-SR 2 mg

Our assessment

The evidence shows that ProThera Melatonin-SR 2 mg is a supplement designed for sleep support, but you should be aware that data specific to this product's ingredients is limited. The primary active ingredient, melatonin, is not covered in the provided data, and no clinical studies or safety reports for melatonin are available here. For the ingredient calcium, which may be present in some formulations, the NIH ODS confirms it supports bone mineralization and neuromuscular relaxation [NIH ODS]. However, for ProThera Melatonin-SR specifically, critical information on efficacy and dosing is not available from the data provided.

How it works

Think of calcium as a foundational mineral — it works through bone mineralization to support bone density and mineral deposition, and it also promotes neuromuscular relaxation by supporting muscle relaxation and nerve signaling [NIH ODS]. For the melatonin component, the mechanism of action is not described in the provided data, so we cannot explain how the sustained-release formulation functions. Data on how this specific product works is not available.

Safety profile

FDA received a total of 592,059 adverse event reports across all supplements, but specific report counts for ProThera Melatonin-SR 2 mg are not available [FDA data]. For calcium, high intakes might increase the risk of heart disease and prostate cancer, and high levels in the blood and urine can cause poor muscle tone, poor kidney function, low phosphate levels, constipation, nausea, weight loss, extreme tiredness, frequent need to urinate, abnormal heart rhythms, and a high risk of death from heart disease [NIH ODS]. Calcium can also reduce the absorption of bisphosphonates, tetracycline antibiotics, fluoroquinolone antibiotics, levothyroxine, and phenytoin [NIH ODS]. Side effects and report counts for melatonin are not available in the provided data.

Our recommendation

Given the lack of specific data on ProThera Melatonin-SR 2 mg, we cannot provide a confident recommendation for this product. If you are considering a melatonin supplement, consult your healthcare provider to discuss your sleep concerns and review any available clinical evidence. For calcium, the data supports its role in bone health, but you should monitor your total intake from all sources and be aware of potential interactions with medications [NIH ODS]. Always start with the lowest effective dose and report any adverse effects to your doctor and the FDA.

Supplement labels contain several key sections regulated by the FDA:

• Serving Size — The recommended amount per dose. Always check this — some products require multiple capsules per serving.
• Amount Per Serving — Shows the quantity of each nutrient in the product, typically in IU (International Units), mg (milligrams), or mcg (micrograms).
• % Daily Value (%DV) — Indicates how much a nutrient in a serving contributes to a daily diet. 5% DV or less is low; 20% DV or more is high.
• Other Ingredients — Lists inactive ingredients like fillers, binders, and capsule materials (e.g., gelatin, cellulose, magnesium stearate).
• Suggested Use — The manufacturer's recommended directions for taking the supplement, including timing and dosage.

Source: FDA Dietary Supplement Labeling Guide