Natural Factors Stress-Relax Melatonin 1 mg

Our assessment

The evidence shows that while this product contains melatonin, the provided data does not include any specific information on melatonin itself. Our assessment must rely solely on the Calcium data provided. For calcium, the data shows it supports bone density and neuromuscular relaxation [NIH ODS]. However, for a product labeled as a stress-relax melatonin supplement, the specific effects of melatonin are not covered in the provided data.

How it works

The only ingredient with mechanism data provided is calcium. Think of calcium as a key structural component for your skeleton and a signal regulator for your nerves and muscles. It supports bone mineralization and helps facilitate muscle relaxation and nerve signaling [NIH ODS]. For the intended purpose of stress and relaxation, this mechanism is relevant, but data on how melatonin works is not available.

Safety profile

Overall, the FDA has received 592,059 total adverse event reports across all supplements [FDA data]. For calcium specifically, high intakes may increase the risk of heart disease and prostate cancer. High blood and urine levels can cause poor muscle tone, poor kidney function, low phosphate levels, constipation, nausea, weight loss, extreme tiredness, frequent urination, abnormal heart rhythms, and a high risk of death from heart disease [NIH ODS]. Side effect report counts specific to this product are not available.

Our recommendation

Data not available for melatonin. For the calcium component, be aware that it can reduce absorption of medications like bisphosphonates, tetracycline and fluoroquinolone antibiotics, levothyroxine, and phenytoin [NIH ODS]. Because specific data on melatonin is missing from the provided information, we cannot make a confident recommendation on this product for stress relief or sleep. Consult your doctor before use.

Supplement labels contain several key sections regulated by the FDA:

• Serving Size — The recommended amount per dose. Always check this — some products require multiple capsules per serving.
• Amount Per Serving — Shows the quantity of each nutrient in the product, typically in IU (International Units), mg (milligrams), or mcg (micrograms).
• % Daily Value (%DV) — Indicates how much a nutrient in a serving contributes to a daily diet. 5% DV or less is low; 20% DV or more is high.
• Other Ingredients — Lists inactive ingredients like fillers, binders, and capsule materials (e.g., gelatin, cellulose, magnesium stearate).
• Suggested Use — The manufacturer's recommended directions for taking the supplement, including timing and dosage.

Source: FDA Dietary Supplement Labeling Guide