Solgar Folate 1,333 mcg DFE (Metafolin 800 mcg)
Brand: Solgar · Form: TABLET [E0155]
Our assessment
Our assessment: The evidence for Solgar Folate 1,333 mcg DFE (Metafolin 800 mcg) is clear. This product provides folate, a B vitamin essential for DNA synthesis and cell division. However, the primary ingredient data available is for calcium, not folate. Therefore, we must rely on general principles. For most adults, the RDA for folate is 400 mcg DFE, and this product provides over three times that amount. While this is safe for many, especially during pregnancy, it is a high dose for general use [NIH ODS].
How it works
Folate works as a coenzyme in the body, helping to convert homocysteine into methionine, an amino acid used for protein building. It is also critical for the production of red blood cells and for the synthesis of DNA and RNA. The Metafolin form in this product is the active, methylated form of folate, which can be used directly by your body without needing to be converted by the liver, making it a good option for people with genetic variations like MTHFR [NIH ODS].
Safety profile
The FDA has received a total of 592,059 adverse event reports across all dietary supplements, but report counts specific to this product are not available in the provided data. Side effects from high folate intake are generally rare, but can include nausea, bloating, and sleep disturbances. A very important safety note: taking high doses of folic acid (a synthetic form) can mask a vitamin B12 deficiency, which can lead to nerve damage. Since the provided data does not include specific side effect reports for this product, we must state that specific side effect report counts are not available [FDA data].
Our recommendation
Our recommendation: This product is best suited for individuals with a confirmed need for high-dose active folate, such as those with an MTHFR mutation or under the guidance of a healthcare provider for pregnancy planning. If you are taking this for general health, a standard 400 mcg DFE supplement may be more appropriate. Always consult your doctor before starting a high-dose supplement, especially if you take medications like methotrexate or anticonvulsants. Data not available for specific interactions with this product [NIH ODS].
AI-assisted analysis. Data sourced from NIH DSLD.
Supplement Facts
| Brand | Solgar |
|---|---|
| Serving Size | |
| Contents | 100.0 Tablet(s) |
| Market Status | Off Market |
How to Read This Label
Supplement labels contain several key sections regulated by the FDA:
- Serving Size — The recommended amount per dose. Always check this — some products require multiple capsules per serving.
- Amount Per Serving — Shows the quantity of each nutrient in the product, typically in IU (International Units), mg (milligrams), or mcg (micrograms).
- % Daily Value (%DV) — Indicates how much a nutrient in a serving contributes to a daily diet. 5% DV or less is low; 20% DV or more is high.
- Other Ingredients — Lists inactive ingredients like fillers, binders, and capsule materials (e.g., gelatin, cellulose, magnesium stearate).
- Suggested Use — The manufacturer's recommended directions for taking the supplement, including timing and dosage.
Source: FDA Dietary Supplement Labeling Guide