Solgar Folate 1000 mcg (Metafolin 1,000 mcg)

Our assessment

The evidence shows that Solgar Folate 1000 mcg (Metafolin) is a straightforward supplement providing a specific, bioavailable form of folate. Your assessment should focus on whether you need this high dose. The primary ingredient, folate, is a B-vitamin essential for DNA synthesis and cell division. However, note that the data provided does not include specific clinical studies or NIH ODS profiles for folate itself; the only ingredient data available is for calcium, which is not in this product. For your specific product, data on efficacy and mechanism is not available from the provided sources.

How it works

Folate, as a B-vitamin, acts as a coenzyme in the body, helping to create and repair DNA and produce red blood cells. The Metafolin form is the active, methylated version of folate, which can be used directly by the body without needing conversion. However, the provided data does not contain a mechanism of action for folate. The only mechanism listed is for calcium, which involves bone mineralization and neuromuscular relaxation [NIH ODS]. This information does not apply to your Solgar Folate supplement.

Safety profile

Data on side effects for this specific product is not available from the provided FDA data, which covers a total of 592,059 adverse event reports across all supplements but does not break them down by ingredient. The only safety data provided is for calcium, which includes risks of constipation, nausea, and abnormal heart rhythms at high intakes [NIH ODS]. This does not apply to your folate supplement. For Solgar Folate 1000 mcg, specific side effect report counts are not available.

Our recommendation

Your decision to take Solgar Folate 1000 mcg should be based on a known need, such as a diagnosed deficiency, pregnancy, or a genetic variation affecting folate metabolism. The 1,000 mcg dose is higher than the standard RDA for most adults. Because specific safety and efficacy data for this product is not provided, consult your healthcare provider to confirm this dose is appropriate for you and to rule out any interactions with medications, as data on interactions for folate is not included here. Data not available for a full clinical recommendation.

Supplement labels contain several key sections regulated by the FDA:

• Serving Size — The recommended amount per dose. Always check this — some products require multiple capsules per serving.
• Amount Per Serving — Shows the quantity of each nutrient in the product, typically in IU (International Units), mg (milligrams), or mcg (micrograms).
• % Daily Value (%DV) — Indicates how much a nutrient in a serving contributes to a daily diet. 5% DV or less is low; 20% DV or more is high.
• Other Ingredients — Lists inactive ingredients like fillers, binders, and capsule materials (e.g., gelatin, cellulose, magnesium stearate).
• Suggested Use — The manufacturer's recommended directions for taking the supplement, including timing and dosage.

Source: FDA Dietary Supplement Labeling Guide