Pure Encapsulations Melatonin 3 mg

Our assessment

The evidence shows that this product contains 3 mg of melatonin per serving, but the specific data provided does not include clinical studies or detailed health information for melatonin itself. For the ingredient calcium, which is listed in the NIH ODS data, the evidence indicates it supports bone mineralization and neuromuscular relaxation [NIH ODS]. However, because the primary ingredient is melatonin and no specific melatonin data was provided, our assessment is limited: you should be aware that the safety and efficacy of this specific product rely on general understanding, not the data set provided here.

How it works

For the mineral calcium, think of it as a structural building block — it supports bone density and mineral deposition, and it also helps with muscle relaxation and nerve signaling [NIH ODS]. Data for melatonin's mechanism is not available in the provided information.

Safety profile

Based on the FDA adverse event data, there are 592,059 total reports across all supplements, but specific report counts for this product or melatonin alone are not available. For calcium, high intakes might increase the risk of heart disease and prostate cancer, and high levels in the blood can cause poor muscle tone, poor kidney function, low phosphate levels, constipation, nausea, weight loss, extreme tiredness, frequent need to urinate, abnormal heart rhythms, and a high risk of death from heart disease [NIH ODS]. Data on side effects for melatonin specifically is not available in the provided data.

Our recommendation

You should start with caution. Because data on melatonin is not provided here, consult your healthcare provider before using this supplement, especially if you take medications like bisphosphonates, tetracycline antibiotics, fluoroquinolone antibiotics, levothyroxine, or phenytoin, as calcium can reduce their absorption [NIH ODS]. For general supplement safety, choose products from reputable brands and follow label directions. Our recommendation is to seek a product with more complete clinical data before use.

Supplement labels contain several key sections regulated by the FDA:

• Serving Size — The recommended amount per dose. Always check this — some products require multiple capsules per serving.
• Amount Per Serving — Shows the quantity of each nutrient in the product, typically in IU (International Units), mg (milligrams), or mcg (micrograms).
• % Daily Value (%DV) — Indicates how much a nutrient in a serving contributes to a daily diet. 5% DV or less is low; 20% DV or more is high.
• Other Ingredients — Lists inactive ingredients like fillers, binders, and capsule materials (e.g., gelatin, cellulose, magnesium stearate).
• Suggested Use — The manufacturer's recommended directions for taking the supplement, including timing and dosage.

Source: FDA Dietary Supplement Labeling Guide