Pure Encapsulations Melatonin 20 mg
Brand: Pure Encapsulations · Form: CAPSULE [E0159]
Our assessment
The evidence shows that this product contains 20 mg of melatonin, which is a very high dose. Most adults need far less for sleep support. We advise caution because the data on high-dose melatonin is limited, and your body's natural production is typically less than 0.5 mg per night. Starting with a much lower dose is safer and often just as effective.
How it works
Melatonin is a hormone that acts as a master timekeeper for your sleep-wake cycle. It signals to your brain that it is time to prepare for sleep, helping to regulate your internal clock. While it is best known for sleep, it also plays a role in supporting eye health and may help with seasonal mood changes. Data not available for the specific mechanism at 20 mg from the provided sources.
Safety profile
FDA received 592,059 total adverse event reports for supplements overall. For melatonin specifically, side effects at high doses can include headache, dizziness, nausea, and drowsiness the next day. Because this is a 20 mg dose, the risk of next-day grogginess is significantly higher. Data not available for the exact number of reports specific to this product or 20 mg dose. [FDA data]
Our recommendation
We do not recommend starting with a 20 mg dose. Begin with 0.5 to 3 mg taken 30–60 minutes before bed. A 20 mg dose should only be used under the guidance of a healthcare professional, especially if you have a history of autoimmune conditions, are taking blood thinners, or have a seizure disorder. For most people, lower doses are safer and provide the same benefit. [NIH ODS]
AI-assisted analysis. Data sourced from NIH DSLD.
Supplement Facts
| Brand | Pure Encapsulations |
|---|---|
| Serving Size | |
| Contents | 60.0 Capsule(s) |
| Market Status | Off Market |
How to Read This Label
Supplement labels contain several key sections regulated by the FDA:
- Serving Size — The recommended amount per dose. Always check this — some products require multiple capsules per serving.
- Amount Per Serving — Shows the quantity of each nutrient in the product, typically in IU (International Units), mg (milligrams), or mcg (micrograms).
- % Daily Value (%DV) — Indicates how much a nutrient in a serving contributes to a daily diet. 5% DV or less is low; 20% DV or more is high.
- Other Ingredients — Lists inactive ingredients like fillers, binders, and capsule materials (e.g., gelatin, cellulose, magnesium stearate).
- Suggested Use — The manufacturer's recommended directions for taking the supplement, including timing and dosage.
Source: FDA Dietary Supplement Labeling Guide