Solgar Folate 1,333 MCG DFE (800 MCG Folic acid)

Our assessment

The evidence shows that this product contains 1,333 mcg DFE (800 mcg folic acid) of folate per serving. For most adults, this is a high dose that meets or exceeds the daily requirement, but we must evaluate the specific role of folate alongside the calcium content listed on the label. Data for the calcium ingredient indicates it supports bone mineralization and neuromuscular relaxation [NIH ODS]. However, be aware that high calcium intakes may increase the risk of heart disease and prostate cancer [NIH ODS].

How it works

Think of folate as a critical building block for DNA synthesis and cell division, while calcium acts as a master regulator for bone density and nerve signaling [NIH ODS]. Together, they support foundational processes: folate helps your body produce healthy red blood cells, and calcium ensures your muscles and nerves function properly. The specific dosage of folate here is designed to support these processes, particularly during periods of increased need [NIH ODS].

Safety profile

FDA received 592,059 total adverse event reports for all supplement products, though specific report counts for this exact product are not separated. For the calcium component, high levels in the blood and urine can cause poor muscle tone, poor kidney function, low phosphate levels, constipation, nausea, weight loss, extreme tiredness, frequent need to urinate, abnormal heart rhythms, and a high risk of death from heart disease [NIH ODS]. Additionally, calcium can reduce the absorption of several medications, including bisphosphonates, tetracycline antibiotics, fluoroquinolone antibiotics, levothyroxine, and phenytoin [NIH ODS]. Data not available for specific side effects of the folate ingredient.

Our recommendation

Start by confirming with your healthcare provider whether you need this high dose of folate, especially if you are not pregnant or planning pregnancy. Take the supplement with food to aid absorption, and separate calcium intake from other medications by at least two hours to avoid absorption issues [NIH ODS]. Monitor for any signs of nausea, constipation, or unusual tiredness. Choose this product only if your doctor has confirmed you require this specific folate dosage.

Supplement labels contain several key sections regulated by the FDA:

• Serving Size — The recommended amount per dose. Always check this — some products require multiple capsules per serving.
• Amount Per Serving — Shows the quantity of each nutrient in the product, typically in IU (International Units), mg (milligrams), or mcg (micrograms).
• % Daily Value (%DV) — Indicates how much a nutrient in a serving contributes to a daily diet. 5% DV or less is low; 20% DV or more is high.
• Other Ingredients — Lists inactive ingredients like fillers, binders, and capsule materials (e.g., gelatin, cellulose, magnesium stearate).
• Suggested Use — The manufacturer's recommended directions for taking the supplement, including timing and dosage.

Source: FDA Dietary Supplement Labeling Guide