Kirkman P-5-P (Pyridoxal-5-Phosphate) With Magnesium Glycinate
Brand: Kirkman · Form: CAPSULE [E0159] On Market
Our assessment
The evidence shows that Kirkman P-5-P with Magnesium Glycinate is a combination supplement that provides a bioactive form of vitamin B6 (as pyridoxal-5-phosphate) paired with magnesium. Our assessment: This product is best considered as a targeted supplement for individuals who need support for nerve function, neurotransmitter health, and muscle relaxation. The data on the individual components in this formula are relevant, but no specific studies exist on this exact combination product.
How it works
Think of the ingredients in this supplement as working on two key systems. The calcium component, which is listed on the label, supports bone mineralization and neuromuscular relaxation by aiding muscle relaxation and nerve signaling [NIH ODS]. The magnesium glycinate form is known for its calming effect, while the P-5-P (pyridoxal-5-phosphate) is the active form of vitamin B6 that your body can use immediately for neurotransmitter synthesis and amino acid metabolism. Calcium can reduce the absorption of several medications, including bisphosphonates, tetracycline antibiotics, fluoroquinolone antibiotics, levothyroxine, and phenytoin [NIH ODS].
Safety profile
There are 592,059 total adverse event reports in the FDA database for all dietary supplements, but specific report counts for this exact product are not available [FDA data]. For the calcium component, safety data shows that high calcium intakes might increase the risk of heart disease and prostate cancer. High levels of calcium in the blood and urine can cause poor muscle tone, poor kidney function, low phosphate levels, constipation, nausea, weight loss, extreme tiredness, frequent need to urinate, abnormal heart rhythms, and a high risk of death from heart disease [NIH ODS]. Data for the specific side effect profile of the P-5-P and magnesium glycinate combination are not available.
Our recommendation
Our recommendation: This product may be appropriate for you if you need a bioavailable form of B6 and magnesium glycinate for nerve and muscle support. However, because specific safety and efficacy data for this combination are not available, you should consult your healthcare provider before starting it. Be particularly cautious if you take any medications that interact with calcium, such as thyroid medication or certain antibiotics. Start with the lowest effective dose and monitor for any side effects.
AI-assisted analysis. Data sourced from NIH DSLD.
Supplement Facts
| Brand | Kirkman |
|---|---|
| Serving Size | |
| Contents | 100.0 Capsule(s) |
| Market Status | On Market |
How to Read This Label
Supplement labels contain several key sections regulated by the FDA:
- Serving Size — The recommended amount per dose. Always check this — some products require multiple capsules per serving.
- Amount Per Serving — Shows the quantity of each nutrient in the product, typically in IU (International Units), mg (milligrams), or mcg (micrograms).
- % Daily Value (%DV) — Indicates how much a nutrient in a serving contributes to a daily diet. 5% DV or less is low; 20% DV or more is high.
- Other Ingredients — Lists inactive ingredients like fillers, binders, and capsule materials (e.g., gelatin, cellulose, magnesium stearate).
- Suggested Use — The manufacturer's recommended directions for taking the supplement, including timing and dosage.
Source: FDA Dietary Supplement Labeling Guide