1 Up Nutrition BCAA's Glutamine & Collagen Pineapple

Our assessment

The evidence shows that this product is a combination supplement, and your primary concern should be the calcium content. Our assessment: while the BCAA, glutamine, and collagen components may offer general support for muscle recovery, the calcium in this formula requires careful attention. You should be aware that calcium can interact with several medications and carries specific risks if your intake is already high [NIH ODS].

How it works

Think of calcium as a structural mineral — it is essential for bone mineralization and supports bone density. It also plays a role in neuromuscular relaxation, helping your muscles relax and your nerves signal properly [NIH ODS]. The BCAA and glutamine in this product are generally used to support muscle protein synthesis and recovery, while collagen provides amino acids that support connective tissue.

Safety profile

Data not available for total adverse events specific to this product. However, FDA has received 592059 total reports across all supplements. For calcium specifically, high intakes might increase the risk of heart disease and prostate cancer. High levels of calcium in the blood and urine can cause poor muscle tone, poor kidney function, low phosphate levels, constipation, nausea, weight loss, extreme tiredness, frequent need to urinate, abnormal heart rhythms, and a high risk of death from heart disease [NIH ODS]. Additionally, calcium can reduce the absorption of several medications, including bisphosphonates, tetracycline antibiotics, fluoroquinolone antibiotics, levothyroxine, and phenytoin [NIH ODS].

Our recommendation

Our recommendation: do not take this supplement without first calculating your total daily calcium intake from food and other supplements. If you are already taking a calcium supplement or eating a diet rich in dairy, fortified foods, or leafy greens, adding this product could push you into a range associated with side effects [NIH ODS]. If you take any of the listed medications, separate your dose of this product by at least two hours, or consult your pharmacist [NIH ODS].

Supplement labels contain several key sections regulated by the FDA:

• Serving Size — The recommended amount per dose. Always check this — some products require multiple capsules per serving.
• Amount Per Serving — Shows the quantity of each nutrient in the product, typically in IU (International Units), mg (milligrams), or mcg (micrograms).
• % Daily Value (%DV) — Indicates how much a nutrient in a serving contributes to a daily diet. 5% DV or less is low; 20% DV or more is high.
• Other Ingredients — Lists inactive ingredients like fillers, binders, and capsule materials (e.g., gelatin, cellulose, magnesium stearate).
• Suggested Use — The manufacturer's recommended directions for taking the supplement, including timing and dosage.

Source: FDA Dietary Supplement Labeling Guide