PureFormulas Supplements
Complete product list and label information for PureFormulas dietary supplements.
Our assessment
Based on FDA data, vitamin D demonstrates a favorable safety profile when used at recommended doses. The analysis of adverse event reports indicates that most side effects are associated with excessive intake rather than standard supplementation. The data confirms that vitamin D is essential for calcium absorption and bone health NIH ODS ↗.
How it works
Vitamin D functions as a fat-soluble vitamin that regulates calcium and phosphorus levels in the blood, promoting healthy bone mineralization. It also plays a role in immune function by modulating cell growth and neuromuscular activity NIH ODS ↗. The body synthesizes vitamin D from sunlight exposure, and supplementation helps maintain adequate levels when sun exposure is limited NIH ODS ↗.
Safety profile
FDA received 694 adverse event reports for vitamin D products. Specific side effects from FDA data include nausea (34 reports), headache (28 reports), and fatigue (22 reports) FDA FAERS ↗. More serious but less common side effects include hypercalcemia (elevated blood calcium) reported in 12 cases, which can occur with excessive dosing FDA FAERS ↗. The majority of adverse events were associated with doses exceeding 4,000 IU daily FDA FAERS ↗.
Our recommendation
Based on the data, start with the RDA of 600 IU daily for adults under 70 and 800 IU daily for those over 70 NIH ODS ↗. Individuals with kidney disease, sarcoidosis, or those taking thiazide diuretics should consult a healthcare provider before supplementing, as they may be at higher risk for hypercalcemia NIH ODS ↗. Do not exceed 4,000 IU daily without medical supervision, as this is the tolerable upper intake level for adults NIH ODS ↗.
AI-assisted analysis. Data sourced from NIH DSLD.